Factors enhancing lycopene production by a new Mycobacterium aurum mutant
2004
Kerr, S. | Cale, C. | Cabral, J.M.S. | Keulen, F van
A mutant strain of Mycobacterium aurum was isolated that produced mainly lycopene (>80%) with a total carotenoid content of 1.2 mg g-1 dry biomass when grown on yeast extract and glucose. Lycopene content of the cells could be significantly increased, up to 7.4 mg g-1 biomass, by growing the cells at suboptimal initial culture pH (pH 6-6.4) or by using high salt concentration (85 mM NaCl) in the culture medium, although a 25-40% decrease in biomass production occurred in both cases. Highest productivity (4 mg lycopene l-1 d-1) was obtained by cultivating the cells at pH 6.
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