Facile access to 3,5-symmetrically disubstituted 1,2,4-thiadiazoles through phosphovanadomolybdic acid catalyzed aerobic oxidative dimerization of primary thioamides

Yajima, Kazuhisa; Yamaguchi, Kazuya; Mizuno, Noritaka

Facile access to 3,5-symmetrically disubstituted 1,2,4-thiadiazoles through phosphovanadomolybdic acid catalyzed aerobic oxidative dimerization of primary thioamides

2014

Yajima, Kazuhisa | Yamaguchi, Kazuya | Mizuno, Noritaka

In the presence of Keggin-type phosphovanadomolybdic acids, e.g., H₆PV₃Mo₉O₄₀, oxidative dimerization of various kinds of primary thioamides including aromatic, heterocyclic, and aliphatic ones efficiently proceeded to give the corresponding 3,5-disubstituted 1,2,4-thiadiazoles in excellent yields.

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