Tuning the organelle specificity and cytotoxicity of iridium(iii) photosensitisers for enhanced phototheranostic applications

Zhu, Jing-Hui; Xu, Guang-Xi; Shum, Justin; Lee, Lawrence Cho-Cheung; Lo, Kenneth Kam-Wing

Tuning the organelle specificity and cytotoxicity of iridium(iii) photosensitisers for enhanced phototheranostic applications

2021

Zhu, Jing-Hui | Xu, Guang-Xi | Shum, Justin | Lee, Lawrence Cho-Cheung | Lo, Kenneth Kam-Wing

Luminescent cyclometallated iridium(iii) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.

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