Tuning the organelle specificity and cytotoxicity of iridium(iii) photosensitisers for enhanced phototheranostic applications
2021
Zhu, Jing-Hui | Xu, Guang-Xi | Shum, Justin | Lee, Lawrence Cho-Cheung | Lo, Kenneth Kam-Wing
Luminescent cyclometallated iridium(iii) complexes with a polyhedral oligomeric silsesquioxane (POSS) unit were designed as efficient theranostic agents that displayed tuneable organelle-targeting properties, minimal dark cytotoxicity and substantial photocytotoxicity even under hypoxic conditions.
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