Anti-inflammatory constituents from Phyllostachys makinoi Hayata
2022
Liaw, Chia-Ching | Lin, Yu-Chi | Wu, Shao-Yu | Kuo, Jenny Chun-Ling | Lin, Zhi-Hu | Lin, Kai-Wei | Hui-Chi, Huang | Yang Kuo, Li-Ming | Kuo, Yao-Haur
A novel chromone analogue, phyllomakin A (1), and a new flavonolignan, (-)-quiquelignan C (2), along with 18 phenolic and 2 triterpenoids, were isolated from the leaves of Phyllostachys makinoi Hayata. The structures of 1–22 were elucidated by an application of various spectroscopic analyses (1D & 2D NMR and MS) and compared with reported data. A biological evaluation showed that compound 3 had very potent anti-NO production activity (IC₅₀ = 4.80 µM), while compounds 2, 6, 11, and 15 showed moderate inhibitory effects (IC₅₀ = 10.19, 13.26, 13.56, and 10.96 µM, respectively) without affecting cell viability at 20 μM.
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