Construction of β-Trifluoromethyl Enol Ether via Base-Promoted C–O Coupling and Rearrangement of Hydrogen Atom

Dai, Kun; Wang, Guan; Li, Yang; Chen, Jian'gang; Liu, Zhong-Wen; Lu, Jian; Liu, Zhao-Tie

Construction of β-Trifluoromethyl Enol Ether via Base-Promoted C–O Coupling and Rearrangement of Hydrogen Atom

2017

A novel, high-efficiency and high-selectivity construction of β-trifluoromethyl enol ether via base-induced/promoted C–O coupling of trifluoromethylated vinyl chloride and phenols is presented with a broad substrate scope. The reaction mechanism, especially the significantly high selectivity, was excavated and understood via DFT calculation and is well supported by the experimental observation.

显示更多 [+]