Organocatalytic Knoevenagel Condensations by Means of Carbamic Acid Ammonium Salts

Mase, Nobuyuki; Horibe, Takuya

Organocatalytic Knoevenagel Condensations by Means of Carbamic Acid Ammonium Salts

2013

Mase, Nobuyuki | Horibe, Takuya

The Knoevenagel condensation between an active methylene compound and an aromatic aldehyde with a carbamic acid ammonium salt used as an organocatalyst gave the desired Knoevenagel products in up to 98% yield. The reaction occurred at rt and in a short reaction time under solvent-free conditions. In addition, no extraction, wash, or chromatography steps were needed to obtain a high-purity Knoevenagel product.

显示更多 [+]