Organocatalytic Knoevenagel Condensations by Means of Carbamic Acid Ammonium Salts
2013
Mase, Nobuyuki | Horibe, Takuya
The Knoevenagel condensation between an active methylene compound and an aromatic aldehyde with a carbamic acid ammonium salt used as an organocatalyst gave the desired Knoevenagel products in up to 98% yield. The reaction occurred at rt and in a short reaction time under solvent-free conditions. In addition, no extraction, wash, or chromatography steps were needed to obtain a high-purity Knoevenagel product.
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