Rhodium acetate/base-catalyzed N-silylation of indole derivatives with hydrosilanes

Itagaki, Shintaro; Kamata, Keigo; Yamaguchi, Kazuya; Mizuno, Noritaka

Rhodium acetate/base-catalyzed N-silylation of indole derivatives with hydrosilanes

2012

Itagaki, Shintaro | Kamata, Keigo | Yamaguchi, Kazuya | Mizuno, Noritaka

In the presence of Rh₂(OAc)₄ (OAc = acetate) and TBA₂WO₄ (TBA = tetra-n-butylammonium), the N-silylation of indole derivatives with hydrosilanes efficiently proceeded to give the corresponding N-silylated indoles in high yields. Pyrrole and carbazole were also N-silylated with the combined catalysts.

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