A practical one-pot procedure for the synthesis of N–H isoquinolones
2013
Lu, Shaonan | Lin, Yingfu | Zhong, Hongban | Zhao, Kang | Huang, Jianhui
A practical one-pot procedure for the preparation of N–H isoquinolones has been developed. This 2-step process via C–H activation of N-alkoxyl benzamides and NaH-mediated dealkoxylation reaction has been demonstrated to be a high yielding alternative methodology for the efficient synthesis of a wide range of representative N–H isoquiolones. In addition, the experimental precedent supported mechanism of the dealkoxylation reaction was also proposed.
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书目信息
出版者
Elsevier Ltd
其它主题
Organometallics; Pd-catalysis; N–o bond cleavage; Benzamides; C–h activation; Isoquinolone
语言
英语
类型
Journal Article; Text
2024-02-28
MODS