Mycotoxins are small molecular weight secondary fungal metabolites and are not immunogenic. However, mycotoxins can be conjugated to a protein or a polypeptide carrier and subsequently be used for immunization. Using this approach, antibodies against a number of mycotoxins have been developed. With the availability of these antibodies, simple and rapid radioimmunoassays (RIA) and enzyme-linked immunosorbent assays (ELISA) for the determination of these mycotoxins in grains and biological fluids have been developed. The present review will cover recent progress on this rapidly developing research area with emphasis on: (1) the approaches used for the preparation of immunogens and antibody production; (2) diversity of specificity of antibodies obtained from various immunogens and (3) different immunochemical approaches that are currently used in mycotoxin analysis.
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ACS Symposium series - American Chemical Society
卷
451
页码
140
- 157
ISSN
0097-6156
出版者
Elsevier B.V.
其它主题
Enzyme-linked immunosorbent assay; Radioimmunoassays
语言
英语
注释
In the series analytic: immunoassays for trace chemical analysis: monitoring toxic chemicals in humans, food, and the environment / edited by m. vanderlaan, l.h. stanker, b.e. watkins, and d.w. roberts.
类型
Text; Journal Article
2024-02-28
MODS