This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20§¡/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4 ¡¿MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.

In the evaluation of anthelmintic efficacy by fecal egg counts for cattle naturally infected with helminths, the reasonable technique of fecal egg counts and the reliable guidelines were determined. Modified technique of Harashigeru and Kim's sedimental tube was the most reasonable in fluke egg counts. Universal egg counting technique was preciser than McMaster egg counting technique and was lower in coefficient variation. Fecal egg counts of pretreatment should be carried out twice and mean of the egg should be calculated

The spectrum of acaricides changes continuously and improves. At the same time, big attention is given to research of new, more effective preparations meeting modern requirements. Research on studying the efficiency of Akaribil preparation against swine sarcoptosis (Sarcoptidae) was realized in the conditions of swine breeding farm in the Republic of Belarus. The preparation possesses high insect-acaricidal activity. In the conditions of the preparation storage and repeated opening of a ware in the course of tests there were stated no changes in drug smell or color. The scheme of the preparation application is applied in industrial production technology. It possesses anti-inflammatory properties, antiseptic stimulating healing of skin damages, does not irritate integuments, renders weak irritating effect on mucous membranes of eyes. In recommended doses Akaribil does not cause any adverse effects and complicating disease. There were stated no contraindications to preparation application. High therapeutic efficiency against arachnoentomosis was proved. Application the preparation made it possible not only to reduce disease incidence and animal death, but also to facilitate the severity of scabietic diseases. As a result of realized research it was established that efficiency of Akaribil against swine sarcoptosis was 100%.

In the conditions of the Republic of Belarus there were studied the aetiology factors in development of dermatoses of productive cows taking into account the hygienic aspects. Structural defects of floors of cattle livestock buildings in animals of an experimental group promoted higher (on 35%) development of mattery dermhelminthiasis of distal areas of hindlegs in comparison with animals of a control group. Occurrence of skin dermhelminthiasis, especially in distal areas of hindlegs, was caused by various primary traumas of soft parts with the subsequent introduction into them of pathogenic microbial flora. The imperfect design of floors, an unsatisfactory microclimate in cow cattle houses, hypodynamia in the absence of constitutional walk made the preconditions for it. The reasons of purulent dermatosis of cows were two interconnected etiological factors: mechanical damages of tissues and development of a surgical infections in affected areas against the background of unsatisfactory microclimate that led to decrease in dairy efficiency on 4,51%. Therefore in a complex of the actions directed towards the preventive maintenance of surgical diseases, it is necessary to include the strict control over designing, building and operation of cattle-breeding premises, traumatism prevention, creation of an optimum microclimate and observance of zoohygienic norms of cattle maintenance.

In the conditions of the Republic of Belarus taking into consideration the hygienic aspects there were studied the aetiological factors in dermatosis development in productive cows. As a result of realized research it was established that aetiology of skin diseases in the area of a mammary gland were traumas, and following affects were more often marked: skin rhagades of mammillars; wound in the area of a mammary gland and mammillars; fistulas of milk tank vessels; and also sporadic damages of sphincter muscle of teat canal caused by machine milking. This in its turn gives made it possible to consider, that traumas of various character were a contributing factor for occurrence of udder garget - mastitis. In course of the realized analysis there was proved a high therapeutic efficiency of 1% aethonium gel for the treatment of various traumas of mammary gland and udder mammillars of cows. Clinical recovery of animals after administration 1% aethonium gel was stated on 3,2 days earlier, than after administration of Burenushka cream in the postoperative period. Healing and restoring action of 1% aethonium gel for udder tissues was proved by changes in number of somatic cells in milk. The quantity of somatic cells in 7 days after administration of 1% aethonium gel came back to the level which was typical healthy animals, while in the control group the quantity of somatic cells per 1 ml of milk did not decrease essentially.

In the conditions of the Republic of Belarus there was studied a comparative efficacy of methods of drug administration for diseased animals with respiratory diseases. It was stated that enteral (internal) administration of Tromexin in a complex therapy of calves with respiratory pathology possesses rendered low therapeutic efficacy and could have a lethal outcome. Parenteral (intramuscular) administration of Enrotil and Dexafort for a complex therapy of calves with respiratory pathology rendered a moderate therapeutic efficacy and could lead to animal's state improvement. Parenteral (intravenous) administration of hypertonic solutions of norsulfazol, calcium chloride, sodium chloride and glucose in complex therapy of calves diseased with a respiratory pathology proved to render a high therapeutic efficacy and may lead in a complete clinical recovery.

In the conditions of the Republic of Belarus there was studied the antihelmintic characteristics of the preparative forms of marsh cinquefoil (Comarum palustre): herbal infusion, infusion, liquid, extract, pulvis. The research has shown that these preparative forms in the specified dozes had a rather high therapeutic efficiency against strongylatosis of gastro-intestinal tract of young ruminants. The highest therapeutic effect was rendered by a liquid extract of Comarum palustre after its administration to animals in a dose of 0,2 ml/kg twice with 24 hour interval. In this case during the strongylatoses of a gastroenteric tract the antiparasitic intensefficiency of sheep and cattle by the end of experience was 98,1% and 97,3% respectively, and antiparasitic extensefficiency was 90% for both kinds of animals. After herbal infusion application of Comarum palustre for animals (in a dose of 7 ml/kg of live weight before feeding once a day within 3 days continuously) by the end of the 14 day of the experiment made it possible to obtain intensefficiency of 70% for both animal species, and extensefficiency of 60% for sheep and 70% - at calves. Tincture application of marsh cinquefoil for animals in a dose of 1 ml/kg of live weight of twice with 24 hours interval, provided the intensefficiency of 85% for sheep and 84% - for cattle, and extensefficiency of 70% and 80%, respectively. In the conditions of application of a pulvis of marsh cinquefoil in a dose of 500 mg/kg of live weight twice with 24 hours interval, made it possible to obtain the 63,4% intensefficiency for sheep and 67,8% - for calves, and extensive efficiency - 50% and 40%, respectively.

In the conditions of the Republic of Belarus there was determined the influence of lactulose of the clinical state of weanling piglets, as well as analysis of its preventive and therapeutic efficacy. For the experimental group of piglets in course of 5 days before weaning the lactulose for administrated daily in combination with feed in course of 5 days in dose of 0,002 gram per kilogram of live weight. In 3-5 days after weaning the diarrhea was stated in 4,1% of experimental piglets. The clinically evident efficiency of application of the synthetic disaccharide was showed in lowering of disbacteriosis level in weaning piglets on 33,7%. Besides, there was analyzed the therapeutic efficacy of lactulose for weaning piglets diseased with gastroenteritis. They were administrated lactulose in dose of 0,03 grams per kilogram of live weight once a day after feeding in course of 7 days. Haematologic and biochemical blood indexes of experimental and control groups of piglets were analyzed. Research results showed that application of lactulose promoted the creation of optimal conditions for beneficial microflora, stimulated its reproduction, suppressed the development of opportunistic pathogens.

In the conditions of the Republic of Belarus there was studied the propagation, botanical characteristic, chemical composition and pharmacological properties of marsh cinquefoil (Comarum palustre) and its application in the veterinary practice against strongylatosis (Strongylata) of gastrointestinal system of cattle young stock. Reserch results showed that the perennial herbage plant marsh cinquefoil from Rosales (Rosaceae) family possessed different therapeutic properties: antipyretic agent; styptic agent; diuretic agent; bonding agent; wound healing substance; tonic agent; promotoring agent. Research results showed that the preparative forms (broth; liqueur; liquid juice; powder) of marsh cinquefoil possessed an active agent proanthocyanidin, a condensed tanning substance which were included into composition of a polyphenolic complex and proved to be efficient for treatment of cattle young stock strongylatosis.