The present study investigated the toxicologic histopathologie effect ofallatoxin Hi, 60 broiler chicks ol’ one-day aged devided randomly and equally into three groups. for dietary study, using one group as untreated control, while the other groups were given aflatoxin B. mixed with diet in concentration of 0.5 and 1.5 ppm respectively, for 30 days, the study showed fatty degeneration of liver associated with bile duct prolilicration, accompanied by infiltration of monenuclcar cells and lymphocytes. Also there was degeneration in proximal convoluted tubules mostly as hyaline degeneration especially at 0.5 ppm dose level. Those at 1.5 ppm dose level, there was focal liver cell necrosis associated with fibrosis and enlarged proliferated bile ducts. sever vacuolation and necrosis of epithelial of renal proximal convoluted tubules with thickening of the glomerular basement membrane

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Hepatospecific metabolic profile of blood serum in cattle with fat liver dystrophy has been studied. It has been stated that at this pathology the activity of aminotransferases, alkaline phosphatase hses; concentration of common cholesterol increases; lover indices of activity of cholinesterase, gamma-glutamiltranspeptidase and concentranion of serum albumin are observed. There was studied the hepatospecific metabolic profile of blood serum in cattle with fat liver dystrophy. The following biochemical indicators have been included: activity of some enzymes (alaninaminotransferase, aspartataminotransferase, gamma-glutamiltranspeptidase, alkaline phosphatase and cholinesterase), concentration of common protein, serum albumin, common cholesterol and common bilirubin, and also colloidal-sedimentary tests (thymol turbidity test and test on apolipoproteins-b). At fat liver dystrophy the activity of aminotransferases increases, specifying on the cytolytic processes proceeding in hepatocytes. Authentic increase of alkaline phosphatase enzyme and concentration of common cholesterol at animals testifies about developed intrahepatic cholestasia. Decrease of cholinesterase activity, concentration of serum albumin and the tendency to fall of enzyme gamma-glutamiltranspeptidase at fat liver dystrophy specify in infringement of albuminous exchange - a lack of proteosynthetic liver functions. Thus, offered for research hepatospecific metabolic profile of blood serum in cattle with fat liver dystrophy reflects proceeding pathological processes in body. In the tabular form data on activity of hepatic dependent enzymes at cows with fat liver dystrophy in comparison with healthy nonpregnant animals, indicators of colloidal-sedimentary tests, concentration of common protein, serum albumin in blood serum of cows with fat liver dystrophy and at healthy nonpregnant animals are presented.