Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
2021
Bader Al Alwan | Karmen AbuZineh | Shuho Nozue | Aigerim Rakhmatulina | Mansour Aldehaiman | Asma S. Al-Amoodi | Maged F. Serag | Fajr A. Aleisa | Jasmeen S. Merzaban | Satoshi Habuchi
Al Alwan et al. describe the tethering and rolling behaviour of leukemic cells by using a microfluidic platform that mimics the endothelial surface under flow conditions. With single-molecule live cell fluorescence imaging, they show that unique spatiotemporal dynamics of selectin ligands on the membrane tethers and slings play an essential role in the rolling of the cell.
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