Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling

Bader Al Alwan; Karmen AbuZineh; Shuho Nozue; Aigerim Rakhmatulina; Mansour Aldehaiman; Asma S. Al-Amoodi; Maged F. Serag; Fajr A. Aleisa; Jasmeen S. Merzaban; Satoshi Habuchi

Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling

2021

Al Alwan et al. describe the tethering and rolling behaviour of leukemic cells by using a microfluidic platform that mimics the endothelial surface under flow conditions. With single-molecule live cell fluorescence imaging, they show that unique spatiotemporal dynamics of selectin ligands on the membrane tethers and slings play an essential role in the rolling of the cell.

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