Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling
2021
Bader Al Alwan | Karmen AbuZineh | Shuho Nozue | Aigerim Rakhmatulina | Mansour Aldehaiman | Asma S. Al-Amoodi | Maged F. Serag | Fajr A. Aleisa | Jasmeen S. Merzaban | Satoshi Habuchi
Al Alwan et al. describe the tethering and rolling behaviour of leukemic cells by using a microfluidic platform that mimics the endothelial surface under flow conditions. With single-molecule live cell fluorescence imaging, they show that unique spatiotemporal dynamics of selectin ligands on the membrane tethers and slings play an essential role in the rolling of the cell.
Mostrar más [+] Menos [-]Información bibliográfica
Este registro bibliográfico ha sido proporcionado por Directory of Open Access Journals
