The interaction of phosphine with haemoglobin and erythrocytes

Chin, K.L.; Mai, X.; Meaklim, J.; Scollary, G.R.; Leaver, D.D.

The interaction of phosphine with haemoglobin and erythrocytes

1992

Chin, K.L. | Mai, X. | Meaklim, J. | Scollary, G.R. | Leaver, D.D.

Phosphine progressively converts oxyhaemoglobin to methaemoglobin and hemichrome species, with the product formed being time- and concentration-dependent. The reaction of phosphine with oxyhaemoglobin leads to the formation of phosphite and phosphate. Incubation of rat erythrocytes with various concentrations of phosphine results in the progressive uptake of phosphine by the erythrocytes in a temperature-dependent first-order process. Uptake of phosphine by erythrocytes causes crenation, but conversion of oxyhaemoglobin to methaemoglobin and hemichrome could not be demonstrated.

Show more [+]

AGROVOC Keywords

animals biotransformation blood erythrocytes erythrocytes hemoglobin hemolysis insecticides interactions metabolic detoxification metabolism pharmacokinetics phosphine rats rats rats spectral analysis spectrophotometry toxicity

Bibliographic information

Published in

Xenobiotica

Volume 22 Issue 5 Pagination 599 - 607 ISSN 0049-8254

Publisher

American Chemical Society

Other Subjects

Phosphines; Oxyhemoglobin; Methemoglobin; Hemichrome; Phosphine biotransformation; Markers; Uptake; Hemoglobins; Sprague-dawley; Drug effects; Oxyhemoglobins

Language

English

Type

Text; Journal Article

In AGRIS since: 2024-02-28

Format: MODS

Data Provider

This bibliographic record has been provided by National Agricultural Library

Discover this data provider's collection in AGRIS

Lookup at Google Scholar

If you notice any incorrect information relating to this record, please contact us at agris@fao.org