The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

Zhai, Fengguang; Li, Jingyun; Ye, Meng; Jin, Xiaofeng

The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

2022

Zhai, Fengguang | Li, Jingyun | Ye, Meng | Jin, Xiaofeng

Ubiquitination of substrates usually have two fates: one is degraded by 26S proteasome, and the other is non-degradative ubiquitination modification which is associated with cell cycle regulation, chromosome inactivation, protein transportation, tumorigenesis, achondroplasia, and neurological diseases. Cullin3 (CUL3), a scaffold protein, binding with the Bric-a-Brac-Tramtrack-Broad-complex (BTB) domain of substrates recognition adaptor and RING-finger protein 1 (RBX1) form ubiquitin ligases (E3). Based on the current researches, this review has summarized the functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination.

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AGROVOC Keywords

ar carcinogenesis cell cycle chromosomes cns copii ddr genes irak lys mcm sac ser transportation

Bibliographic information

Published in

Gene

Volume 832 Pagination 146562 ISSN 0378-1119

Publisher

Elsevier B.V.

Other Subjects

Tgn; Crls; Edr1/hph1; Crn7; Ctr; Proteasome endopeptidase complex; Rme; Sec; Cul3kbtbd8; Dht; Pca; P62; Nf-κb; Npc; Suz12; Itafs; Aggresomes; Tir; H3k9me3; Ring finger domains; Ubiquitin-protein ligase; Cdt1; Ic3; Adt; Gpcr; Nrf2; Np2; Cdk1; Thr; Xist; Hipk2; Tcof1; E1; Nolc1; G1; Cdc6; Atm; Orc; Cblc; Plk1; Ezh2; Pcr2; Ubiquitin ligases; M1; Npcd; Pre-rc; Btb; Myd88; Eed; E3; Ires; Rbx; E2; Pb1; Hesc; Hd; Prc; Xi; Uim; Vcp/p97; Apc; Ad; Crpc; Skp2; Ring; Incenp; Uba; Pbd; Npl4; Np1; Lc3; Dd; Caax; Khsrp; Sbc; Klhl; Srs; Traf6; Scaffolding proteins; Kt-mt; Spop; Nsclc; Cullin3; Culs; H4k20me2; Tlr; Dgr; Ubiquitination; Mcb; Shrna; Ecm; Tkis; Hr; 53bp1; Udr; Pcr1; Dsbs; G2; Pbip1; Inf2; Er; Non-degradative; Pcg; Nhej; Rna pol i; Pd; Αegfr; Cpc; 17βhsd4

Language

English

Type

Text; Journal Article

In AGRIS since: 2024-02-28

Format: MODS

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Links

DOI https://dx.doi.org/10.1016/j.gene.2022.146562

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