Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

Moustafa Algamal; Alyssa N. Russ; Morgan R. Miller; Steven S. Hou; Megi Maci; Leon P. Munting; Qiuchen Zhao; Dmitry Gerashchenko; Brian J. Bacskai; Ksenia V. Kastanenka

Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

2022

Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.

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Bibliographic information

Publisher

Nature Portfolio

Other Subjects

Biology (general)

Language

English

Type

Journal Article

Source

Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)

In AGRIS since: 2023-03-15

Format: AGRIS AP

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DOI https://doaj.org/article/9442891c7a3244869aae495ba0e754c4 https://doaj.org/toc/2399-3642

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Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

2022

Bibliographic information