Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease
2022
Moustafa Algamal | Alyssa N. Russ | Morgan R. Miller | Steven S. Hou | Megi Maci | Leon P. Munting | Qiuchen Zhao | Dmitry Gerashchenko | Brian J. Bacskai | Ksenia V. Kastanenka
Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.
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