Enterovirus replication: go with the (counter)flow

Nchoutmboube, Jules; Ford-Siltz, Lauren A.; Belov, George A.

Enterovirus replication: go with the (counter)flow

2015

Nchoutmboube, Jules | Ford-Siltz, Lauren A. | Belov, George A.

All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P–cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.

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AGROVOC Keywords

enterovirus lipids virus replication

Bibliographic information

Published in

Trends in microbiology

Volume 23 Issue 4 Pagination 183 - 184 ISSN 0966-842X

Publisher

Elsevier Ltd

Other Subjects

Cholesterol–pi4p exchange; Enterovirus replication organelles; Drug repurposing; Lipid trafficking; Lipid composition; Oxysterol binding protein (osbp)

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-27

Format: MODS

Data Provider

This bibliographic record has been provided by National Agricultural Library

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Links

DOI http://dx.doi.org/10.1016/j.tim.2015.02.008

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