Enterovirus replication: go with the (counter)flow
2015
Nchoutmboube, Jules | Ford-Siltz, Lauren A. | Belov, George A.
All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P–cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.
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书目信息
Trends in microbiology
卷
23
期
4
页码
183
- 184
ISSN
0966-842X
出版者
Elsevier Ltd
其它主题
Cholesterol–pi4p exchange; Enterovirus replication organelles; Drug repurposing; Lipid trafficking; Lipid composition; Oxysterol binding protein (osbp)
语言
英语
类型
Journal Article; Text
2024-02-27
MODS
