Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs

Millichamp, N.J.; Dziezyc, J.; Rohde, B.H.; Chiou, G.C.Y.; Smith, W.B.

Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs

1991

Millichamp, N.J. | Dziezyc, J. | Rohde, B.H. | Chiou, G.C.Y. | Smith, W.B.

Dogs were treated with flunixin meglumine, a cyclo-oxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.

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AGROVOC Keywords

alkaloids analysis animals chemistry diameter dogs dogs drug therapy eicosanoids etiology eyes flunixin inflammation pharmacology uveitis

Bibliographic information

Published in

American journal of veterinary research

Volume 52 Issue 8 Pagination 1279 - 1284 ISSN 0002-9645

Other Subjects

Anti-inflammatory agents; Drug effects; Non-steroidal; Anti-inflammatory agents; Internal pressure; Adverse effects; Intraocular pressure; Dinoprostone; Veterinary; Benzofurans; Analogs & derivatives; Dog diseases; Matrine; Pupil diameter; Aqueous humor; Lipoxygenase inhibitors; Pupil; Therapeutic use; Laser therapy; Quinolizines; Clonixin; Leukotriene b4; 5-lipoxygenase inhibitors

Language

English

Note

2019-12-04

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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