Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs

Millichamp, N.J.; Dziezyc, J.; Rohde, B.H.; Chiou, G.C.Y.; Smith, W.B.

Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs

1991

Millichamp, N.J. | Dziezyc, J. | Rohde, B.H. | Chiou, G.C.Y. | Smith, W.B.

Dogs were treated with flunixin meglumine, a cyclo-oxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.

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Mots clés AGROVOC

alkaloids analysis animals chemistry diameter dogs dogs drug therapy eicosanoids etiology eyes flunixin inflammation pharmacology uveitis

Informations bibliographiques

Publié dans

American journal of veterinary research

Volume 52 Numéro 8 Pagination 1279 - 1284 ISSN 0002-9645

D'autres materias

Anti-inflammatory agents; Drug effects; Non-steroidal; Anti-inflammatory agents; Internal pressure; Adverse effects; Intraocular pressure; Dinoprostone; Veterinary; Benzofurans; Analogs & derivatives; Dog diseases; Matrine; Pupil diameter; Aqueous humor; Lipoxygenase inhibitors; Pupil; Therapeutic use; Laser therapy; Quinolizines; Clonixin; Leukotriene b4; 5-lipoxygenase inhibitors

Langue

anglais

Note

2019-12-04

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

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