Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs

Millichamp, N.J.; Dziezyc, J.; Rohde, B.H.; Chiou, G.C.Y.; Smith, W.B.

Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs

1991

Millichamp, N.J. | Dziezyc, J. | Rohde, B.H. | Chiou, G.C.Y. | Smith, W.B.

Dogs were treated with flunixin meglumine, a cyclo-oxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.

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Palabras clave de AGROVOC

alkaloids analysis animals chemistry diameter dogs dogs drug therapy eicosanoids etiology eyes flunixin inflammation pharmacology uveitis

Información bibliográfica

Publicado en

American journal of veterinary research

Volumen 52 Edición 8 Paginación 1279 - 1284 ISSN 0002-9645

Otras materias

Anti-inflammatory agents; Drug effects; Non-steroidal; Anti-inflammatory agents; Internal pressure; Adverse effects; Intraocular pressure; Dinoprostone; Veterinary; Benzofurans; Analogs & derivatives; Dog diseases; Matrine; Pupil diameter; Aqueous humor; Lipoxygenase inhibitors; Pupil; Therapeutic use; Laser therapy; Quinolizines; Clonixin; Leukotriene b4; 5-lipoxygenase inhibitors

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Nota

2019-12-04

Tipo

Journal Article; Text

En AGRIS desde: 2024-02-28

Formato: MODS

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