Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation

Sen, Sajal; Li, Yue; Lynch, Vincent; Arumugam, Kuppuswamy; Sessler, Jonathan L.; Arambula, Jonathan F.

Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation

2019

We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(i) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines.

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AGROVOC Keywords

amines chemical reactions fluorescence gold humans image analysis

Bibliographic information

Published in

Chemical communications

Volume 55 Issue 71 Pagination 10627 - 10630 ISSN 1364-548X

Publisher

The Royal Society of Chemistry

Other Subjects

Neoplasm cells; Cell proliferation; Human cell lines; In vitro studies

Language

English

License

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Type

Text; Journal Article

In AGRIS since: 2024-02-28

Format: MODS

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Links

DOI http://dx.doi.org/10.1039/c9cc05635a

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