Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation

Sen, Sajal; Li, Yue; Lynch, Vincent; Arumugam, Kuppuswamy; Sessler, Jonathan L.; Arambula, Jonathan F.

Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation

2019

We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(i) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines.

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Ключевые слова АГРОВОК

amines chemical reactions fluorescence gold humans image analysis

Библиографическая информация

Опубликовано в

Chemical communications

Том 55 Выпуск 71 Нумерация страниц 10627 - 10630 ISSN 1364-548X

Издатель

The Royal Society of Chemistry

Другие темы

Human cell lines; Neoplasm cells; In vitro studies; Cell proliferation

Язык

Английский

Лицензия

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Тип

Journal Article; Text

В АГРИСе с: 2024-02-28

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

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Ссылки

DOI http://dx.doi.org/10.1039/c9cc05635a

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