Role of sphinogomyelin in cellular cholesterol homeostasis

Rudney, H.; Gupta, A.K.

Role of sphinogomyelin in cellular cholesterol homeostasis

1992

Rudney, H. | Gupta, A.K.

When the ratio of sphingomyelin to cholesterol in cellular membranes is disturbed, cellular cholesterol metabolism is modulated. This report reviews some of the disturbances in cholesterol biosynthesis which occur after treatment of cells in culture with exogenous sphingomyelinase from S. aureus. Treatment of LDL with the same sphingomyelinase preparation results in >90% reduction of the sphingomyelin content of the LDL particle and greatly enhances processing of LDL.

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AGROVOC Keywords

cell lines cholesterol mammals sphingomyelins

Bibliographic information

Published in

ACS Symposium series - American Chemical Society

Volume 497 Pagination 238-245 - 245 ISSN 0097-6156

Publisher

Elsevier B.V.

Other Subjects

Plasma membrane; Cholesterol metabolism; Regulation; Low density lipoprotein

Language

English

Note

In the series analytic: regulation of isopentenoid metabolism / edited by w.d. nes, e.j. parish, and j.m. trzaskos. paper presented at the 201st national meeting, april 14-19, 1991, atlanta, georgia.

Type

Journal Article; Text

In AGRIS since: 2024-02-29

Format: MODS

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Role of sphinogomyelin in cellular cholesterol homeostasis

1992

AGROVOC Keywords

Bibliographic information