Role of sphinogomyelin in cellular cholesterol homeostasis
1992
Rudney, H. | Gupta, A.K.
When the ratio of sphingomyelin to cholesterol in cellular membranes is disturbed, cellular cholesterol metabolism is modulated. This report reviews some of the disturbances in cholesterol biosynthesis which occur after treatment of cells in culture with exogenous sphingomyelinase from S. aureus. Treatment of LDL with the same sphingomyelinase preparation results in >90% reduction of the sphingomyelin content of the LDL particle and greatly enhances processing of LDL.
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