Results of serological examinations of blood serum of sheep on revelation of virus respiratory infections (parainfluenza-3, adenovirus and respiratory syncytial) realized in the conditions of the Kyrgyz Republic were presented. Research results showed that in farm and peasant farm holdings of all studied districts of the Kyrgyz Republic of three types of pneumo viral infections simultaneously give high levels of antibody titers in relation to parainfluenza-3 – 1:128, adenovirus – 1:32, respiratory syncytial infection – 1:16. In some districts sheep population was diseased only by parainfluenzal infection in relation with titer of specific antibodies 1:256

In the conditions of the Republic of Belarus the seasonal derangements of metabolic processes at high-producing cows usually take place in the period from March till May. Analysis of efficiency of application of national preparation CMP (complex-mineral preparation -iron (15 mg/ml); iodine (6,8 mg/ml); magnesium (6,0 mg/ml); selenium (0,32 mg/ml) and vitamin preparation Trivitim (vitamin A – 30000 IU; , vitamin D – 40000 IU; vitamin E – 20 mg) for the preserving of high milking yielding capacity and prevention of metabolic processes disorders was realized. Four groups of high productive cows were formed. First group was entered 10 ml of CMP intramuscular; cows of the second group were entered 10 ml of Trivitim intramuscular; cows of the third group were entered CMP and Trivitim in the same doses; and the fourth group was a controlled one. On the 1-st, 7-th and 15-th days there was realized evaluation animal clinical state, hematologic and biochemical blood indexes (leukocytes; erythrocytes; hemoglobin; thrombocytes; ESR; total protein; albumins; urea; creatinine; glucose; calcium; phosphorous; magnesium; iron), and average daily milk yield. There was also analyzed the phagocytic activity of neutrophilic leukocytes. Research results showed that content of leukocytes and ESR in blood in all experimental groups was within the standard limits. In the first experimental group there was state the increasing of hemoglobin (from 91,4 +/- 4,38 up to 111,83 +/- 4,3 g/l (P less than0,05) ) and erythrocytes (from 4,48 +/- 0,21 up to 5,97 +/- 0,45 10E12/l) content. The same changes were stated in cows of the 2-d and 3-d experimental groups. Content of hemoglobin and erythrocyte in blood of cows which were administrated with CMP and Trivitim increased from 90,6 +/- 0,06 to 99,83 +/- 3,61 g/l and from 4,51 +/- 0,27 to 5,55 +/- 0,28 10E12/l, respectively. Analyze of biochemical indexes of cow blood showed that content of total protein, calcium, phosphorus, magnesium and iron increased. On the 15-th day there was stated the decrease of urea. Research results proved that the combined application of CMP and Trivitim was efficient and prevented subclinical disorders of metabolic processes

Evaluation of safety and efficiency of application of immunostimulative drug Izambenum (C14H15IN2O) for stimulation of natural resistance (autarcesis) and immunologic responsiveness of chickens of laying breeds was realized in the conditions of the Republic of Belarus. Clinical and experimental investigation of Izambenum influence on poultry for the increasing of their resistance, activation of immunological response to vaccination against Newcastle disease, stimulation of their growth and development was realized. Research results showed that Izambenum influenced on level of morphological indexes of chicken blood: number of erythrocytes increased on 24%, hemoglobin - on 17%. Total protein in blood serum increased in all test period and number of lymphocytes increased and differential was 90-100%. Izambenum increased strains of post vaccination immunity to Newcastle disease. Bacterial growth-inhibitory activity decreased on the 27the day of life and increased at the same positions on the 34-41 days. Phagocyte activity of pseudoeosinophils increased in all test groups. Research results showed that Izambenum rendered growth and immunity stimulation action and increased their viability. Its immunostimulative action was conditioned by strengthening of cellular and to lower extent humoral immunity factors. Application of the preparation in period of Newcastle disease vaccination promoted the formation of long-lived immunity

Investigation of efficiency of electrochemically active solutions in complex therapy of calves with diseases of the digestive apparatus and respiratory organs was realized in the conditions of the Republic of Belarus. Calves diseased with dyspepsia and bronchopneumonia were chosen for investigation of gastrointestinal diseases and respiratory diseases. At the first stage there was studied the therapeutic efficacy of water solution of electrochemically active neutral anolyte and sodium hypochloride solution Akvamed for calves sick with dyspepsia. At the second stage there was analyzed the therapeutic efficacy of 0,04 % solution sodium hypochloride Akvamed for the treatment of bronchopneumonia of calves. Research results showed that inclusion into complex therapeutic regimen of calves of electrochemically active solutions promoted the reduction of disease duration and severity. Electrochemically active solutions had high biocidal activity and could be produced in large volumes, had practical safety, low price and acute therapeutic effect

The article features the data on scientific research of the spread and etiology of bovine dermatophytoses. Work was carried out in 2007-2009 in farm holdings of Minsk and Vitebsk regions of the Republic of Belarus. Principal causes of diseases occurrence are the mechanical traumas caused first of all by infringement of animals maintenance of hygienic norms, also infringement of animals feeding technology. The automicroflora on intact skin has been studied. Realized study helped to determine methods and means of dermatophytoses treatment.

Serological properties of leptospirae bacteria grown on differential nutritive media were studied by the example of sheep in the conditions of the Republic of Belarus. In the experiment there were used 6 pathogenic industrial leptospirae stock: Leptospira pomona VGNKI-6; Leptospira tarassovi VGNKI-4; Leptospira grippothyphosa VGNKI-1; Leptospira icterrohaemorragia VGNKI-2; Leptospira conicola VGNKI-3; Leptospira hardjo VGNKI-5. The results showed a serological difference of leptospirae grown on conventional and experimental media derived from ram's blood.

The realized studies of an experimental series of inactivated vaccine showed that the developed biological preparation made it possible to achieve high preventive efficiency in the conditions of cows heavy with calves for the creation in newborn calves the expressing immunity after milk feeding in the first hours of their life. As a result realized in the conditions of the Republic of Belarus production experiment of emulsified vaccine against rotavirus infection and colibacillosis of cattle in animal breeding farms of different regions of the Republic the prophylactic efficacy of a developed vaccine made up 97,9-98,9%. Research results showed that the developed inactivated vaccine caused at the immunizated animals the formation of specific antibodies at a higher level in comparison with other analyzed national and foreign analogue preparations.

Data on changes of infectious titer of Porcine Reproductive & Respiratory Syndrome (PRRS) virus depending on variability of cultivation conditions was analyzed in the conditions of the Republic of Belarus. There were determined the regimes of cultivation which made it possible to minimize the terms of virus containing material production up to 3 days. The following factors influenced the infectious titer of PRRS: adaptation to cell culture; completeness of cell culture monolayer; number cells moving into stage of logarithmic growth; infectious dose of virus; storage duration; usage intensity.

Investigation of histological structures of liver of fattening broiler chickens after application of concentrate of E and F vitamins produced on the basis of rapeseed oil was realized in the conditions of the Republic of Belarus in order to evaluate their efficiency for prophylaxis of massive hepatic necrosis. Research results showed that application of the vitamins on the basis of rapeseed oil promoted the support of structural properties of hepatic cells that proved their higher antioxidant efficiency in comparison with synthetic vitamin analogues

A description of a method of chemical inactivation of Aujeszky's disease virus by teotropin was studied in the conditions of the Republic of Belarus. The developed inactivated viral suspension was tested for its antigenic activity. On the basis of realized experiments there were determined the optimal parameters of inactivation of Aujeszky's disease virus y means of 0,1% solution of teotropin under temperature of 37 deg C, pH 7,8 and duration of exposition of 24 hours. There were studied indexes of antigenic activity of inactivated virus