A facile, environmentally benign sulfonamide synthesis in water
2006
Tang, Siu-Fu | Mani, Neelakandha S.
A facile, environmentally benign synthesis of sulfonamides under dynamic pH control in aqueous media is described. This methodology uses equimolar amounts of amino compounds and arylsulfonyl chlorides and omits the use of organic bases. Isolation of products involves only filtration after acidification. Excellent yields and purity were obtained without further purification.
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