Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

Nakayama, Atsushi; Okano, Akinori; Feng, Yiqing; Collins, James C.; Collins, Karen C.; Walsh, Christopher; Boger, Dale L.

Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

2014

Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.

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Palabras clave de AGROVOC

chemical structure glycosyltransferases organic compounds

Información bibliográfica

Publicado en

Organic letters

Volumen 16 Edición 13 Paginación 3572 - 3575 ISSN 1523-7052

Editorial

American Chemical Society

Otras materias

Vancomycin; Glycosylation

Idioma

Inglés

Licencia

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Tipo

Journal Article; Text

En AGRIS desde: 2024-02-29

Formato: MODS

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Enlaces

DOI http://dx.doi.org/10.1021%2Fol501568t

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