Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

Nakayama, Atsushi; Okano, Akinori; Feng, Yiqing; Collins, James C.; Collins, Karen C.; Walsh, Christopher; Boger, Dale L.

Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

2014

Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.

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Ключевые слова АГРОВОК

chemical structure glycosyltransferases organic compounds

Библиографическая информация

Опубликовано в

Organic letters

Том 16 Выпуск 13 Нумерация страниц 3572 - 3575 ISSN 1523-7052

Издатель

American Chemical Society

Другие темы

Vancomycin; Glycosylation

Язык

Английский

Лицензия

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Тип

Journal Article; Text

В АГРИСе с: 2024-02-29

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

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Ссылки

DOI http://dx.doi.org/10.1021%2Fol501568t

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