Egg yolk soluble protein stimulated the proliferation and differentiation of osteoblastic MC3T3-E1 cells
2007
Ji, M.Y.(Pharma Foods International Co. Ltd., Kyoto (Japan)) | Leem, K.H. | Kim, M. | Kim, H.K.
We determined the effects of yolk water-soluble protein (YSP) on bone formation in pre-osteoblastic MC3T3-E1 cells. YSP (50-5000 micro g/ml) increased cell proliferation and collagen content. Alkaline phosphatase (ALP) activity was also increased by YSP treatment. After enhancement of ALP activity, significant augmentation of calcification was observed. These results suggest that YSP is a promising agent for the prevention and treatment of bone loss.
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