Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

Suo, Xin-yue; Shi, Meng-jiao; Dang, Jun; Yue, Hui-lan; Tao, Yan-duo; Zhen, Bo; Wang, Jia-jia; Wang, Xue; Sun, Hao-ran; Sun, Hua; Qiang, Gui-fen; Ji, Teng-fei; Liu, Bo

Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

2021

Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of Hypericum genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C (1) and hyperacmosin D (2) were isolated from H. acmosepalum. Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound 1 showed significant hepatoprotective activity at 10 µM against paracetamol-induced HepG2 cell damage and compound 2 could moderately increase the relative glucose consumption.

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Mots clés AGROVOC

clusiaceae glucose hypericum research

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Publié dans

Journal of Asian natural products research

Volume 23 Numéro 11 Pagination 1068-1076 - 1076 ISSN 1477-2213

Editeur

American Chemical Society

D'autres materias

Human cell lines; Hepatoprotective effect; Hypericum acmosepalum; Ppaps; Relative glucose consumption; Circular dichroism spectroscopy; Hepatoprotective activity; Ecd

Langue

anglais

Note

This research was funded by Projects of International Cooperation and Exchanges NSFC (NSFC-VR, No. 81361138020), National Science and Technology Major Projects for “Major New Drugs Innovation and Development”, Research and Development of New Drug Varieties from Natural Product Sources and Their Key Innovative Technological Systems (No. 2018ZX09711001-001-001 and 2018ZX09711001-001-003) and the CAMS Innovation Fund for Medical Sciences (CIFMS), the CAMS Initiative for Innovative Medicine (CAMS-I2M, No. 2016-I2M-1-010).

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

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Cette notice bibliographique a été fournie par National Agricultural Library

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DOI DOI https://dx.doi.org/10.1080/10286020.2021.1880395

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Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

2021

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Informations bibliographiques