Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum
2021
Suo, Xin-yue | Shi, Meng-jiao | Dang, Jun | Yue, Hui-lan | Tao, Yan-duo | Zhen, Bo | Wang, Jia-jia | Wang, Xue | Sun, Hao-ran | Sun, Hua | Qiang, Gui-fen | Ji, Teng-fei | Liu, Bo
Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of Hypericum genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C (1) and hyperacmosin D (2) were isolated from H. acmosepalum. Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound 1 showed significant hepatoprotective activity at 10 µM against paracetamol-induced HepG2 cell damage and compound 2 could moderately increase the relative glucose consumption.
显示更多 [+] 显示较少 [-]