Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

Suo, Xin-yue; Shi, Meng-jiao; Dang, Jun; Yue, Hui-lan; Tao, Yan-duo; Zhen, Bo; Wang, Jia-jia; Wang, Xue; Sun, Hao-ran; Sun, Hua; Qiang, Gui-fen; Ji, Teng-fei; Liu, Bo

Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

2021

Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of Hypericum genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C (1) and hyperacmosin D (2) were isolated from H. acmosepalum. Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound 1 showed significant hepatoprotective activity at 10 µM against paracetamol-induced HepG2 cell damage and compound 2 could moderately increase the relative glucose consumption.

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Ключевые слова АГРОВОК

clusiaceae glucose hypericum research

Библиографическая информация

Опубликовано в

Journal of Asian natural products research

Том 23 Выпуск 11 Нумерация страниц 1068-1076 - 1076 ISSN 1477-2213

Издатель

American Chemical Society

Другие темы

Human cell lines; Hepatoprotective effect; Hypericum acmosepalum; Ppaps; Relative glucose consumption; Circular dichroism spectroscopy; Hepatoprotective activity; Ecd

Язык

Английский

Примечание

This research was funded by Projects of International Cooperation and Exchanges NSFC (NSFC-VR, No. 81361138020), National Science and Technology Major Projects for “Major New Drugs Innovation and Development”, Research and Development of New Drug Varieties from Natural Product Sources and Their Key Innovative Technological Systems (No. 2018ZX09711001-001-001 and 2018ZX09711001-001-003) and the CAMS Innovation Fund for Medical Sciences (CIFMS), the CAMS Initiative for Innovative Medicine (CAMS-I2M, No. 2016-I2M-1-010).

Тип

Journal Article; Text

В АГРИСе с: 2024-02-28

Формат: MODS

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Эту запись предоставил National Agricultural Library

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Ссылки

DOI DOI https://dx.doi.org/10.1080/10286020.2021.1880395

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ФАО АГРИС — международная информационная система по сельскохозяйственным наукам и технологиям

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Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum

2021

Ключевые слова АГРОВОК

Библиографическая информация