Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites
2017
Morris, Patrick J. | Moaddel, Ruin | Zanos, Panos | Moore, Curtis E. | Gould, Todd | Zarate, Carlos A. | Thomas, Craig J.
Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxynorketamines. At least two hydroxynorketamines have significant antidepressant action in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12 hydroxynorketamines and their binding affinity to the NMDA receptor is presented here.
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