Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites
2017
Morris, Patrick J. | Moaddel, Ruin | Zanos, Panos | Moore, Curtis E. | Gould, Todd | Zarate, Carlos A. | Thomas, Craig J.
Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxynorketamines. At least two hydroxynorketamines have significant antidepressant action in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12 hydroxynorketamines and their binding affinity to the NMDA receptor is presented here.
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书目信息
Organic letters
卷
19
期
17
页码
4572
- 4575
ISSN
1523-7052
出版者
American Chemical Society
其它主题
Binding capacity; Antidepressants
语言
英语
许可
//data.crossref.org/schemas/AccessIndicators.xsd:license_ref>http://purl.org/eprint/accessRights/OpenAccess | //data.crossref.org/schemas/AccessIndicators.xsd:program>//data.crossref.org/schemas/AccessIndicators.xsd:license_ref> | //data.crossref.org/schemas/AccessIndicators.xsd:program>
类型
Text; Journal Article
2024-02-28
MODS
