Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites
2017
Morris, Patrick J. | Moaddel, Ruin | Zanos, Panos | Moore, Curtis E. | Gould, Todd | Zarate, Carlos A. | Thomas, Craig J.
Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxynorketamines. At least two hydroxynorketamines have significant antidepressant action in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12 hydroxynorketamines and their binding affinity to the NMDA receptor is presented here.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por National Agricultural Library
