HMDO-Promoted Peptide and Protein Synthesis in Ionic Liquids
2013
Duan, Jianli | Sun, Yao | Chen, Hao | Qiu, Guofu | Zhou, Haibing | Tang, Ting | Deng, Zixin | Hong, Xuechuan
Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63–94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.
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