HMDO-Promoted Peptide and Protein Synthesis in Ionic Liquids
2013
Duan, Jianli | Sun, Yao | Chen, Hao | Qiu, Guofu | Zhou, Haibing | Tang, Ting | Deng, Zixin | Hong, Xuechuan
Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63–94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.
Mostrar más [+] Menos [-]Palabras clave de AGROVOC
Información bibliográfica
Este registro bibliográfico ha sido proporcionado por National Agricultural Library
