Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf

Saunders, G. K.; Wenger, D. A.

Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf

2008

Saunders, G. K. | Wenger, D. A.

A 5-month-old Hereford calf with neurologic disease was euthanatized, and a necropsy was done. No gross lesions were seen in the brain. Microscopically, neurons throughout the brain and spinal cord had distended, foamy vacuolated cytoplasm. Ultrastructure showed clear vacuoles filling the neuronal cytoplasm. A lysosomal storage disease was suspected. Sphingomyelinase deficiency was confirmed by biochemical analysis of liver and brain.

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Mots clés AGROVOC

animals bovines brain brain calves cattle enzyme activity histopathology liver lysosomes microscopy pathology sphingomyelins spinal cord spinal cord ultrastructure

Informations bibliographiques

Publié dans

Veterinary pathology

Numéro 2 Pagination 201 - 202 ISSN 1544-2217

Editeur

SAGE Publications

D'autres materias

Sphingomyelinase; Niemann-pick; Phosphoric diester hydrolases; Neuron; Veterinary; Histocytochemistry; Hereford; Cattle diseases; Enzyme deficiencies; Niemann-pick diseases; Neurons; Electron; Inherited metabolic diseases; Lysosomal storage; Male; Fatal outcome

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-29

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI https://dx.doi.org/10.1354/vp.45-2-201

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