Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf

Saunders, G. K.; Wenger, D. A.

Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf

2008

Saunders, G. K. | Wenger, D. A.

A 5-month-old Hereford calf with neurologic disease was euthanatized, and a necropsy was done. No gross lesions were seen in the brain. Microscopically, neurons throughout the brain and spinal cord had distended, foamy vacuolated cytoplasm. Ultrastructure showed clear vacuoles filling the neuronal cytoplasm. A lysosomal storage disease was suspected. Sphingomyelinase deficiency was confirmed by biochemical analysis of liver and brain.

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Ключевые слова АГРОВОК

animals bovines brain brain calves cattle enzyme activity histopathology liver lysosomes microscopy pathology sphingomyelins spinal cord spinal cord ultrastructure

Библиографическая информация

Опубликовано в

Veterinary pathology

Выпуск 2 Нумерация страниц 201 - 202 ISSN 1544-2217

Издатель

SAGE Publications

Другие темы

Sphingomyelinase; Niemann-pick; Phosphoric diester hydrolases; Neuron; Veterinary; Histocytochemistry; Hereford; Cattle diseases; Enzyme deficiencies; Niemann-pick diseases; Neurons; Electron; Inherited metabolic diseases; Lysosomal storage; Male; Fatal outcome

Язык

Английский

Тип

Journal Article; Text

В АГРИСе с: 2024-02-29

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

Откройте коллекцию этого поставщика данных в AGRIS

Ссылки

DOI https://dx.doi.org/10.1354/vp.45-2-201

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