Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf

Saunders, G. K.; Wenger, D. A.

Sphingomyelinase Deficiency (Niemann-Pick disease) in a Hereford Calf

2008

Saunders, G. K. | Wenger, D. A.

A 5-month-old Hereford calf with neurologic disease was euthanatized, and a necropsy was done. No gross lesions were seen in the brain. Microscopically, neurons throughout the brain and spinal cord had distended, foamy vacuolated cytoplasm. Ultrastructure showed clear vacuoles filling the neuronal cytoplasm. A lysosomal storage disease was suspected. Sphingomyelinase deficiency was confirmed by biochemical analysis of liver and brain.

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Palabras clave de AGROVOC

animals bovines brain brain calves cattle enzyme activity histopathology liver lysosomes microscopy pathology sphingomyelins spinal cord spinal cord ultrastructure

Información bibliográfica

Publicado en

Veterinary pathology

Edición 2 Paginación 201 - 202 ISSN 1544-2217

Editorial

SAGE Publications

Otras materias

Sphingomyelinase; Niemann-pick; Phosphoric diester hydrolases; Neuron; Veterinary; Histocytochemistry; Hereford; Cattle diseases; Enzyme deficiencies; Niemann-pick diseases; Neurons; Electron; Inherited metabolic diseases; Lysosomal storage; Male; Fatal outcome

Idioma

Inglés

Tipo

Journal Article; Text

En AGRIS desde: 2024-02-29

Formato: MODS

Proveedor de Datos

Este registro bibliográfico ha sido proporcionado por National Agricultural Library

Descubra la colección de este proveedor de datos en AGRIS

Enlaces

DOI https://dx.doi.org/10.1354/vp.45-2-201

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