Enantioselective synthesis of both enantiomers of dimethyl cis-(4-acetoxycyclopent-2-enyl)malonate, key intermediates for epijasmonate

Tanimori, S.; Tsuji, Y.; Kirihata, M.

Enantioselective synthesis of both enantiomers of dimethyl cis-(4-acetoxycyclopent-2-enyl)malonate, key intermediates for epijasmonate

2002

Tanimori, S. (Osaka Prefectural Univ., Sakai (Japan)) | Tsuji, Y. | Kirihata, M.

Both enantiomers (3 and 4) of dimethyl cis-(4-acetoxycyclopent-2-enyl)ma!onate (3), known intermediates for the synthesis of epijasmonate, were prepared in an enantio-enriched form from common starting material 2 based on desymmetrization of the m&yo-character by palladium-catalyzed asymmetric allylic alkylation.

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