Isolation and Characterization of Helicobacter pylori Urease Inhibitor from Rubus coreanus Miquel

Yang, S.W.;Ho, J.N.;Lee, Y.H.;Shin, D.H.;Hong, B.S.;Cho, H.Y.E-mail:hycho@korea.ac.kr

Isolation and Characterization of Helicobacter pylori Urease Inhibitor from Rubus coreanus Miquel

Yang, S.W.;Ho, J.N.;Lee, Y.H.;Shin, D.H.;Hong, B.S.;Cho, H.Y.(Korea University, Seoul, Republic of Korea)E-mail:hycho@korea.ac.kr

A Helicobacter pylori urease inhibitor from Rubus coreanus Miquel has been isolated and partially characterized for aiming to prevent H. pylori growth and decrease harmful accumulation of ammonia in human gastric mucosa. We screened urease inhibitory activities in 519 extracts library prepared by solvent extractioin from 173 kinds of edible plants, medicinal herbs, herbs and seaweeds using a colorimetric urease assay system. As results of primary and secondary screening, 70% acetone extract of Rubus coreanus Miquel was selected as potent candidate, showing about 24% inhibitory activity. The acetone extract was sequentially partitioned into RCE/RCWI and RCB/RCW2 layers with ethyl acetate and butanol.

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Ключевые слова АГРОВОК

helicobacter pylori inhibidores de la ureasa urease inhibitors 분리

Библиографическая информация

Опубликовано в

Journal of The Korean Society of Food Science and Nutrition

Том 33 Выпуск 5 ISSN 1226-3311

Нумерация страниц

pp. 769-777

Другие темы

복분자; Urease inhibitor; Inhibiteur de l'urease; Helicobacter pylori urease inhibitor; Rubus coreanus miquel

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Примечание

Summary(En)

3 tables

6ill., 45 ref.

Переведенный заголовок

복분자(Rubus coreanus Miquel)로부터 Helicobacter pylori Urease Inhibitor의 분리 및 특성

Тип

AGRIS — международная информационная система по сельскохозяйственным наукам и технологиям

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Isolation and Characterization of Helicobacter pylori Urease Inhibitor from Rubus coreanus Miquel

Ключевые слова АГРОВОК

Библиографическая информация