Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
2014
Cheung, Chi Wai | Buchwald, Stephen L.
A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.
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书目信息
Journal of organic chemistry
卷
79
期
11
页码
5351
- 5358
ISSN
1520-6904
出版者
American Chemical Society
其它主题
Cross-coupling reactions; Organic chemistry
语言
英语
许可
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类型
Journal Article; Text
2024-02-28
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