Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

Cheung, Chi Wai; Buchwald, Stephen L.

Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

2014

Cheung, Chi Wai | Buchwald, Stephen L.

A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

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Ключевые слова АГРОВОК

catalysts catalytic activity cesium chemical structure hydroxides hydroxylation ligands organic halogen compounds palladium phenols potassium

Библиографическая информация

Опубликовано в

Journal of organic chemistry

Том 79 Выпуск 11 Нумерация страниц 5351 - 5358 ISSN 1520-6904

Издатель

American Chemical Society

Другие темы

Cross-coupling reactions; Organic chemistry

Язык

Английский

Лицензия

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Тип

Journal Article; Text

В АГРИСе с: 2024-02-28

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

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Ссылки

DOI http://dx.doi.org/10.1021%2Fjo500662s

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