Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

Cheung, Chi Wai; Buchwald, Stephen L.

Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst

2014

Cheung, Chi Wai | Buchwald, Stephen L.

A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

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Palabras clave de AGROVOC

catalysts catalytic activity cesium chemical structure hydroxides hydroxylation ligands organic halogen compounds palladium phenols potassium

Información bibliográfica

Publicado en

Journal of organic chemistry

Volumen 79 Edición 11 Paginación 5351 - 5358 ISSN 1520-6904

Editorial

American Chemical Society

Otras materias

Cross-coupling reactions; Organic chemistry

Idioma

Inglés

Licencia

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Tipo

Journal Article; Text

En AGRIS desde: 2024-02-28

Formato: MODS

Proveedor de Datos

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Enlaces

DOI http://dx.doi.org/10.1021%2Fjo500662s

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